职称及职务：副教授，硕士生导师
研究方向：炎症反应的调控机制研究及相关新药设计
邮箱：yuzhang@hust.edu.cn
地址：武汉市航空路13号同济医学院药学院二号楼604室
教育及工作经历：
2018-至今华中科技大学药学院，副教授
2014-2018华中科技大学药学院，讲师
2009-2014武汉大学，理学博士（导师：舒红兵 院士）
2005-2009兰州大学，理学学士
主持科研项目：
国家自然科学基金面上项目：《ANGPTL3/8复合物调控NF-kB活化和炎症的功能及机制研究》，项目批准号31871411
国家自然科学基金青年基金：《Betatrophin对TNFa或IL-1b诱导NF-kB活化的负调控机制研究》，项目批准号31500706
湖北省自然科学基金青年基金：《Betatrophin对糖尿病中NF-kB激活的调节机制研究》，项目批准号2015CFB245
第一/通讯作者论文：
[1]Y. Zhang, W. Xue, W. Zhang, Y. Yuan, X. Zhu, Q. Wang, Y. Wei, D. Yang, C. Yang, Y. Chen, Y. Sun, S. Wang, K. Huang, L. Zheng, Histone methyltransferase G9a protects against acute liver injury through GSTP1, Cell death and differentiation, 27 (2020) 1243-1258.
[2]Y. Zhang, X. Guo, W. Yan, Y. Chen, M. Ke, C. Cheng, X. Zhu, W. Xue, Q. Zhou, L. Zheng, S. Wang, B. Wu, X. Liu, L. Ma, L. Huang, K. Huang, ANGPTL8 negatively regulates NF-kappaB activation by facilitating selective autophagic degradation of IKKgamma, Nature communications, 8 (2017) 2164.
[3] Q. Zhou, C. Cheng, Y. Wei, J. Yang, W. Zhou, Q. Song, M. Ke, W. Yan, L. Zheng,Y. Zhang, K. Huang, USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3, The FEBS journal, 287 (2020) 3165-3183.
[4]Y. Zhang, Y. Zhao, Z. Wang, H. Gong, L. Ma, D. Sun, C. Yang, Y. Li, B. Cheng, R.B. Petersen, F. Jiang, G. Liu, K. Huang, Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-beta(1-42), Biochimica et biophysica acta. General subjects, 1862 (2018) 2226-2235.
[5]Y. Zhang, L. Zheng, K. Huang, A new way to regulate inflammation: selective autophagic degradation of IKKgamma mediated by ANGPTL8, Cell stress, 2 (2018) 66-68.
[6]Y. Zhang, C.Q. Lei, Y.H. Hu, T. Xia, M. Li, B. Zhong, H.B. Shu, Kruppel-like factor 6 is a co-activator of NF-kappaB that mediates p65-dependent transcription of selected downstream genes, The Journal of biological chemistry, 289 (2014) 12876-12885.
