黄建耿，男，博士，副教授，硕士研究生导师。
联系方式：jiangenghuang@hust.edu.cn
研究方向：药代动力学研究（药物体内转运与代谢）
教育背景:
博士 2008.07 华中科技大学同济医学院药学院
本科 2003.07 华中科技大学同济医学院(原同济医科大学)药学院
工作经历:
副教授 2012.04-至今华中科技大学同济医学院药学院
博士后 2010.08-2012.03 美国University of Iowa药学院
兼职讲师 2011.08-2011.11 美国Drake University药学院
博士后2008.10-2010.07 美国University of Nebraska Medical Center药学院
主持科研课题：
1.国家自然科学基金项目：α-突触核蛋白调控uptake 2转运体：多巴胺受体激动剂抗帕金森降效机制研究2018.01-2021.12 课题编号：81773811
2.企业委托项目：苦荞麦提取物体内代谢谱研究 2018.03-2018.12
3.国家自然科学基金项目：基于NTCP/Ntcp和BSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究2014.01-2016.12 课题编号：81302837
4.湖北省自然科学基金项目：基于胆汁酸代谢的药物性肝损伤诊断研究2014.01-2015.12 课题编号：2014CFB956
5.湖北省卫生厅青年科技人才项目：普拉克索鼻黏膜给药脑靶向治疗帕金森及其跨鼻黏膜转运机制研究2013.01-2014.12 课题编号：QJX2012-02
代表作：
1. Yang Hu#, Wenwen Zhu#, Yeli Guan, Sanlan Wu, Xiaoyin Zhang, Gao Li, Luqin Si*, Jiangeng Huang*. Accurate determination of a novel vasodilatory β‐blocker TJ0711 using LC‐MS/MS: Resolution of an isobaric metabolite interference in dog plasma.Biomed Chromatogr. 2018 Jun;32(6):e4196. doi: 10.1002/bmc.4196. (#Both authors contributed equally)
2. Sijie He#, Sanlan Wu#, Wenwen Zhu, Yeli Guan, Gao Li, Luqin Si*, Jiangeng Huang*. Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by LC–MS/MS.J Sep Sci. 2017, DOI: 10.1002/jssc.201700710(#Both authors contributed equally)
3. Li Kang#, Luqin Si#, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.Toxicol In Vitro. 2017, 40:313-323. (#Both authors contributed equally)
4. Mengzhu Zheng#, Weiguang Sun#, Suyu Gao#, Shanshan Luan, Dan Li, Renqi Chen, Qian Zhang, Lixia Chen*, Jiangeng Huang* and Hua Li*. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1.Oncotarget. 2017, 8:44255-44265.
5. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si,Sijie He,JialingCai, Jiangeng Huang*, Maureen D. Donovan*.The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues.Chemosphere.2016,145:487-494.
6.Peng Cao,Gao Li,Ling Huang,Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*.Screeningof stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite indogwhole blood.Bioanalysis.2015,8(17):1823-1835.
7.Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*.Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma byUFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug.J Chromatogr B Analyt Technol Biomed Life Sci.2015,990:141-149.
8.Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*.Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry.J Sep Sci. 2015,38(11):1837-1849.
9.Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MSanalysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange modebasedsolid-phase extraction.J Chromatogr B Analyt Technol Biomed Life Sci.2015,988:157-165.
10.Jiangeng Huang,Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitroenantioselective metabolism ofTJ0711 hydrochlorideby human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci.2012, 891-892:98-101.
11.Jiangeng Huang,Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography.J Chromatogr A.2012, 1219:66-74.
12.Jiangeng Huang,Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitrometabolic stability and metaboliteprofilingof TJ0711 hydrochloride, a newly developed vasodilatoryβ-blocker, using a liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci.2011, 879(30):3386-3392.
13.Jiangeng Huang,Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*. UPLC-MS/MSquantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues.J Chromatogr B Analyt Technol Biomed Life Sci.2011, 879(23):2332-2338.
14.Jiangeng Huang,Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma,bile, andurineusing LC-MS/MS.J Pharm Biomed Anal. 2011, 55(5):1111-1119.
15.Jiangeng Huang,Sai Praneeth R. Bathena, Yazen Alnouti*.Metabolite profilingofPraziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer.Drug Metab Pharmacokinet.2010,25(5):487-499.
16.Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).Xenobiotica. 2010, 40(3):184-194.
17.Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li.Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.Int J Pharm. 2008, 356(1-2):351-353.
学术任职
2018.04--至今 国家食品药品监督管理局药物临床试验数据核查检查员
2017.11--至今 中国药理学会药物代谢专业委员会青年委员会委员
2017.11--至今 国际药物及化学异物代谢学会（ISSX）会员
2015.05--至今 国家自然科学基金委评审专家
2015.01--至今 教育部学位论文评审专家
2014.05--至今 《医药导报》编委
2013.04--至今 武汉市药学会药学教育专业委员会委员
2012.12--2017.11 中国抗癌协会纳米肿瘤学专业委员会委员
2010.10--至今 美国药学科学家协会（AAPS）会员
