孙伟光,博士,男,河南商丘人,生物药学系。主要从事植物与真菌来源天然产物的活行评价及作用机制研究,研究重点为天然来源抗神经退行性疾病、抗肿瘤、抗代谢性疾病先导化合物的发现,以第一作者(或共一)或通讯作者发表SCI论文二十余篇,在Angewandte Chemie-International Edition、Cell Communication and Signaling、Organic Letters、Journal of Natural Products、Marine Drugs等专业权威期刊发表论文二十余篇。主持国家自然科学基金青年基金一项。
联系方式
邮箱:weiguang_sun@hust.edu.cn
地址:武汉市硚口区航空路13号同济医学院药学院1号楼334室邮编430030
研究方向
(1)天然药物活性评价、作用靶点反向虚拟筛选和机制研究
(2)基于蛋白质结构的药物设计与发现
教育与工作经历
2020/7~至今,华中科技大学,讲师
2016/7~2020/6,华中科技大学,博士后,合作导师:张勇慧教授、王小川教授
2010/9~2016/6,华中科技大学,药物化学,博士,导师:张勇慧教授
主持科研项目
(1)国家自然科学基金,项目批准号:81703580,金线莲苷衍生物降糖活性和作用机制研究,2018.01~2020.12,20万元,主持,在研。
(2)重大新药创制,2011ZX09102-006-05,中药6.1类治疗类风湿关节炎新药复方鹿角霜片临床前研究,2011/01~2014/12,150万元,参与,已结题。
(3)重大新药创制,2011ZX09102-004-01,化药1.1类新药PTP1B抑制剂KD10临床前研究,2011/01~2015/12,500万元,参与,已结题。
主要学术论文(#Co-first author, * Corresponding author)
(1)Weiguang Sun(#), Shanshan Luan(#), Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), Yonghui Zhang(*). Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Communication and Signaling,Cell Communication and Signaling.2019; 17(1):111.
(2)Mengting Liu(#),Weiguang Sun(#),Ling Shen, Yan He, Junjun Liu, Jianping Wang, Zhengxi Hu(*), and Yonghui Zhang(*). Bipolarolides A-G, Ophiobolin-Derived Sesterterpenes Representing Three New Carbon Skeletons from Bipolaris sp. TJ403-B1.Angew Chem Int Ed Engl. 2019 ;58(35):12091-12095.
(3)Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang,Weiguang Sun(*), Hucheng Zhu(*), and Yonghui Zhang(*), Niduterpenoids A and B: Two Sesterterpenoids with a Highly Congested Hexacyclic 5/5/5/5/3/5 Ring System from the Fungus Aspergillus nidulans.Organic Letters.2019. 21(7): 2290-2293
(4)Fengli Li(#),Weiguang Sun(#),Jiankun Guan(#), Yuanyuan Lu(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang(*), Zhengxi Hu(*), and Yonghui Zhang(*), Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR‑γ Agonistic Activity from Alternaria brassicicola.Organic Letters. 2018, 20(24):7982-7986.
(5)Zhengxi Hu(#),Weiguang Sun(#),Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), and Yonghui Zhang(*), Fusicoccane-Derived Diterpenoids from Alternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of a IKKβ Inhibitor,Organic Letters. 2018, 20, 5198–5202.
(6)Keliang Chen(#), Xuwen Zhang(#),Weiguang Sun(#),Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li,ZengweiLuo, Yongbo Xue, Hucheng Zhu(*), and Yonghui Zhang(*).Manginoids A−G: Seven Monoterpene−Shikimate-Conjugated Meroterpenoids with a Spiro Ring System from Guignardia mangiferae.Organic Letters.2017, 3;19(21):5956-5959.
(7)Weiguang Sun(#), Xintao Chen(#), Qingyi Tong(#), Hucheng Zhu, Yan He1, Liang Lei, Yongbo Xue, Guangmin Yao, Zengwei Luo, Jianping Wang(*), Hua Li(*), Yonghui Zhang(*). Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune.Scientific Reports.2016; 6: 26418.