万落生，博士
E-mail:wanluosheng@hust.edu.cn; TeL：13797014209
教育及工作经历
2017.11-至今，华中科技大学，副教授，硕士生导师；
2016.09-2017.11，华中科技大学，讲师，硕士生导师；
2013.07-2016.06，中国科学院昆明植物研究所，药学博士后；
2008.09-2013.06，华中科技大学，药理学博士；
2004.09-2008.06，华中科技大学，生物药学学士.
研究方向
中药活性物质基础；药食两用植物功能性成分挖掘
科研项目
1.以Kv1.3离子通道为靶点的大戟属植物抗银屑病药效物质基础研究,国家自然科学基金面上项目，59万元，主持人
2.滇产三种黄杨属植物抗肿瘤作用及资源品质评价，国家自然科学基金青年项目，23万元，主持人
代表性论文(*corresponding author,#first author)
1.Zhou J, Pan J, Xiang Z, Wang Q, Tong Q, Fang J,Wan L*, Chen J*. Data on the optimization of the formula ofXiaokeyinshuiextract combination treating diabetes mellitus using uniform experimental design in mice. Data in Brief, 2020, 32: 106134.
2.Zhou J, Pan J, Xiang Z, Wang Q, Tong Q, Fang J,Wan L*, Chen J*. Xiaokeyinshui extract combination, a berberine-containing agent, exerts anti-diabetic and renal protective effects on rats in multi-target mechanisms. Journal of Ethnopharmacology, 2020, 262: 113098.
3.Yong-Long Wang; Zhi-Nan Xiang; Yan Yuan; Jie-Wen Zhou; Luan-Yuan Tian; Jia-Chun Chen*;Luo-Sheng Wan*. Triterpenoid alkaloids from Buxus rugulosa and their cytotoxic activities. Phytochemistry Letters, 2020, 36, 86-90.
4.Yuan Yan, Wang Qiu-Yan, Zhang Jie, Nie Jing, Zhou Cheng-Gao, Yi Wen-Qin,Wan Luo-Sheng*, Chen Jia-Chun*. A new bile acid from the traditional chinese medicine shedan. Journal of Asian Natural Products Research, 2019, PMID: 31535572.
5.Zhou, Jiewen; Wang, Qiuyan; Xiang, Zhinan; Tong, Qilin; Pan, Jun;Wan, Luosheng*; Chen, Jiachun*. Network Pharmacology Analysis of Traditional Chinese Medicine Formula Xiao Ke Yin Shui Treating Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, 2019, 2019: 4202563.
6.Wang, Qiuyan; Zhou, Jiewen; Xiang, Zhinan; Tong, Qilin; Pan, Jun;Wan, Luosheng*; Chen, Jiachun*. Anti-diabetic and renoprotective effects of Cassiae Semen extract in the streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 2019, 2019: 111904.
7.Xiang, Zhi-Nan; Yi, Wen-Qin; Wang, Yong-Long; Shao, Li-Dong; Zhang, Cheng-Qi; Yuan, Yan; Pan, Jun;Wan, Luo-Sheng*;Chen, Jia-Chun*. Buxaustroines A-N, a Series of 17(13→18)abeo-Cycloartenol Triterpenoidal Alkaloids from Buxus austro-yunnanensis and Their Cardioprotective Activities. Journal of Natural Products, 2019, 82, 3111-3120.
8.Luo-Sheng Wan#, Yin Nian#, Xing-Rong Peng, Li-Dong Shao, Xiao-Nian Li, Jian Yang, Ming Zhou, and Ming-Hua Qiu*, Pepluanols C–D, Two Diterpenoids with Two Skeletons from Euphorbia peplus, Organic Letters, 2018, 20, 3074-3120.
9.Yajun Gong, Jie Zhang, Fei Gao, Jiewen Zhou, Zhinan Xiang, Chenggao Zhou,Luosheng Wan*;Jiachun Chen*, Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong, Carbohydrate Polymers, 2017, 173: 215-222.
10.Shi-Tou Bai, Guo-Lei Zhu, Xing-Rong Peng, Jin-Run Dong, Mu-Yuan Yu, Jian-Chao Chen,Luo-Sheng Wan*, Ming-Hua Qiu*, Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines, Molecules, 2016, 21(9): 1125.
11.Luo-Sheng Wan#, Yin Nian#, Chen-Jun Ye#, Li-Dong Shao, Xing-Rong Peng, Chang-An Geng, Zhi-Li Zuo, Xiao-Nian Li, Jian Yang, Ming Zhou*, and Ming-Hua Qiu*, Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus, Organic Letters, 2016, 18 (9): 2166-2169.
12.Luo-Sheng Wan, Li-Dong Shao, Liangbing Fu, Jun Xu, Guo-Lei Zhu, Xing-Rong Peng, Xiao-Nian Li, Yan Li, and Ming-Hua Qiu*, One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction, Organic Letters, 2016, 18 (3): 496-499.
13.Luo-Sheng Wan, Rui Chu, Xing-Rong Peng, Guo-Lei Zhu, Mu-Yuan Yu, Lei Li, Lin Zhou, Shuang-Yang Lu, Jin-Run Dong, Zhi-Run Zhang, Yan Li, and Ming-Hua Qiu*, Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity, Journal of Natural Products, 2016, 79 (6): 1628-1634.
14.Luo-Sheng Wan, Qiu-Xia Min, Yong-Long Wang, Yao-Dong Yue, and Jia-Chun Chen*, Xanthone Glycoside Constituents of Swertia kouitchensis with α-Glucosidase Inhibitory Activity, Journal of Natural Products, 2013, 76 (7): 1248-1253.
15.Luo-Sheng Wan, Ting-Ting Liu, Xiao-Jun Lin, Qiu-Xia Min, Jia-Chun Chen*, Two New Chiratane-Type Triterpenoids from Swertia kouitchensis, Molecules, 2013, 18(7): 8518-8523.
16.Luo-sheng Wan, Cui-ping Chen, Zuo-qi Xiao, Yong-long Wang, Qiu-xia Min, Yuedong Yue, Jiachun Chen*,In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract, Journal of Ethnopharmacology, 2013, 147(3): 622-630.
中药药效物质基础
主持课题情况：
1.滇产三种黄杨属植物抗肿瘤作用及资源品质评价，国家自然科学基金青年项目，23万元
代表性研究成果（第一或者通讯作者）
1.Luo-Sheng Wan#, Yin Nian#, Xing-Rong Peng, Li-Dong Shao, Xiao-Nian Li, Jian Yang, Ming Zhou, and Ming-Hua Qiu*, Pepluanols C–D, Two Diterpenoids with Two Skeletons fromEuphorbia peplus, Organic Letters, 2018, ASAP. DOI:10.1021/acs.orglett.8b01114.
2.Yajun Gong, Jie Zhang, Fei Gao, Jiewen Zhou, Zhinan Xiang, Chenggao Zhou,Luosheng Wan*; Jiachun Chen*, Structure features and in vitro hypoglycemic activities of polysaccharides from different species ofMaidong, Carbohydrate Polymers, 2017, 173: 215-222.
3. Shi-Tou Bai, Guo-Lei Zhu, Xing-Rong Peng, Jin-Run Dong, Mu-Yuan Yu, Jian-Chao Chen,Luo-Sheng Wan*, Ming-Hua Qiu*, Cytotoxicity of Triterpenoid Alkaloids fromBuxus microphyllaagainst Human Tumor Cell Lines, Molecules, 2016, 21(9): 1125.
4.Luo-Sheng Wan#, Yin Nian#, Chen-Jun Ye#, Li-Dong Shao, Xing-Rong Peng, Chang-An Geng, Zhi-Li Zuo, Xiao-Nian Li, Jian Yang, Ming Zhou*, and Ming-Hua Qiu*, Three Minor Diterpenoids with Three Carbon Skeletons fromEuphorbia peplus, Organic Letters, 2016, 18 (9): 2166-2169.
5.Luo-Sheng Wan, Li-Dong Shao, Liangbing Fu, Jun Xu, Guo-Lei Zhu, Xing-Rong Peng, Xiao-Nian Li, Yan Li, and Ming-Hua Qiu*, One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction,Organic Letters, 2016, 18 (3): 496-499.
6.Luo-Sheng Wan, Rui Chu, Xing-Rong Peng, Guo-Lei Zhu, Mu-Yuan Yu, Lei Li, Lin Zhou, Shuang-Yang Lu, Jin-Run Dong, Zhi-Run Zhang, Yan Li, and Ming-Hua Qiu*, Pepluane and Paraliane Diterpenoids fromEuphorbia pepluswith Potential Anti-inflammatory Activity, Journal of Natural Products, 2016, 79 (6): 1628-1634.
7.Luo-Sheng Wan, Qiu-Xia Min, Yong-Long Wang, Yao-Dong Yue, and Jia-Chun Chen*,Xanthone Glycoside Constituents ofSwertia kouitchensiswith α-Glucosidase Inhibitory Activity, Journal of Natural Products, 2013, 76 (7): 1248-1253.
8.Luo-Sheng Wan, Ting-Ting Liu, Xiao-Jun Lin, Qiu-Xia Min, Jia-Chun Chen*,Two New Chiratane-Type Triterpenoids fromSwertia kouitchensis,Molecules, 2013, 18(7): 8518-8523.
9.Luo-sheng Wan, Cui-ping Chen, Zuo-qi Xiao, Yong-long Wang, Qiu-xia Min, Yuedong Yue, Jiachun Chen*,In vitro and in vivo anti-diabetic activity ofSwertia kouitchensisextract,Journal of Ethnopharmacology, 2013, 147(3): 622-630.
